International Journal of Head and Neck Surgery

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VOLUME 13 , ISSUE 4 ( October-December, 2022 ) > List of Articles


Fruits and Nuts! Unique Homeopathic Treatment of Cutaneous Squamous Cell Carcinoma

Skylar Trott, Amit Patel, Tj Gal

Keywords : Alternative treatment, Head and neck cancer, Squamous cell carcinoma

Citation Information : Trott S, Patel A, Gal T. Fruits and Nuts! Unique Homeopathic Treatment of Cutaneous Squamous Cell Carcinoma. Int J Head Neck Surg 2022; 13 (4):109-111.

DOI: 10.5005/jp-journals-10001-1542

License: CC BY-NC 4.0

Published Online: 21-01-2023

Copyright Statement:  Copyright © 2022; The Author(s).


Aim: Cutaneous squamous cell carcinoma (cSCC) of the head and neck is preferentially treated with primary surgical excision. We present a case of an advanced lesion appearing to respond to homeopathic supplementation with bitter apricot seed and hedge apple. Background: Our patient presented with a large, biopsy-proven cSCC of the right nasal ala. Her workup revealed a synchronous primary lung adenocarcinoma necessitating delayed management of the cutaneous lesion. In the interim, she self-treated with oral bitter apricot seed and hedge apple supplements. Case description: The patient demonstrated significant involution of the cutaneous lesion, and eventual surgical resection was negative for carcinoma. Conclusion: The literature has in vitro evidence for the antiproliferative properties of compounds derived from hedge apples. Bitter apricot seed has little evidence supporting anticancer activity and is not recommended due to the risk of cyanide toxicity. However, there is little alternative explanation for her dramatic response other than these substances. Clinical significance: We describe a case of cSCC of the head and neck that appears to have responded to bitter apricot seed and hedge apple.

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  1. American Cancer Society. Key Statistics for Basal and Squamous Cell Skin. Cancers 2011.
  2. Gurudutt VV, Genden EM. Cutaneous squamous cell carcinoma of the head and neck. J Skin Cancer 2011;2011(61):502723. DOI: 10.1155/2011/502723
  3. Leibovitch I, Huilgol SC, Selva D, et al. Cutaneous squamous cell carcinoma treated with Mohs micrographic surgery in Australia I. Experience over 10 years. J Am Acad Dermatol 2005;53(2):253–260. DOI: 10.1016/j.jaad.2005.02.059
  4. Bickers DR, Lim HW, Margolis D, et al. The burden of skin diseases: 2004 a joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology. J Am Acad Dermatol 2006;55(3):490–500. DOI: 10.1016/j.jaad.2006.05.048
  5. National Comprehensive Cancer Network. NCCN Guidelines: Squamous Cell Skin. Cancer (July 2020, January 2021).
  6. Wolfrom M, Benton F, Gregory A, et al. Osage orange pigments. II. Isolation of a new pigment, pomiferin. J Am Chem Soc 1939;61(10):2832–2836. DOI: 10.1021/ja01265a079
  7. Tsao R, Yang R, Young JC. Antioxidant isoflavones in Osage orange, Maclura pomifera (Raf.) Schneid. J Agric Food Chem 2003;51(22):6445–6451. DOI: 10.1021/jf0342369
  8. Vesela D, Kubinova R, Muselik J, et al. Antioxidative and EROD activities of osajin and pomiferin. Fitoterapia 2004;75(2):209–211. DOI: 10.1016/j.fitote.2003.12.005
  9. Yang R, Hanwell H, Zhang J, et al. Antiproliferative activity of pomiferin in normal (MCF-10A) and transformed (MCF-7) breast epithelial cells. J Agric Food Chem 2011;59(24):13328–13336. DOI: 10.1021/jf202898g.
  10. Svasti J, Srisomsap C, Subhasitanont P, et al. Proteomic profiling of cholangiocarcinoma cell line treated with pomiferin from Derris malaccensis. Proteomics 2005;5(17):4504–4509. DOI: 10.1002/pmic.200401315.
  11. Son IH, Chung IM, Lee SI, et al. Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera. Bioorg Med Chem Lett 2007;17(17):4753–4755. DOI: 10.1016/j.bmcl.2007.06.060.
  12. Bajer MM, Kunze MM, Blees JS, et al. Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem Pharmacol 2014;88(3):313–321. DOI: 10.1016/j.bcp.2014.01.034.
  13. Milazzo S, Lejeune S, Ernst E. Laetrile for cancer: a systematic review of the clinical evidence. Support Care Cancer 2007;15(6):583–595. DOI: 10.1007/s00520-006-0168-9
  14. Ellison NM, Byar DP, Newell GR. Special report on laetrile: the NCI laetrile review: results of the National Cancer Institute's retrospective laetrile analysis. New England Journal of Medicine 1978;299(10):549–552. DOI: 10.1056/NEJM197809072991013
  15. Schmidt ES, Newton GW, Sanders SM, et al. Laetrile toxicity studies in dogs. JAMA 1978;239(10):943–947. DOI: 10.1001/jama.1978.03280370039021
  16. Laetrile/Amygdalin (PDQ(R)): Health Professional Version. PDQ Cancer Information Summaries. Bethesda (MD), 2002.
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