Keywords :
Head and neck cancer, Human papillomavirus, Squamous cell carcinoma
Citation Information :
Owusu-Ayim M, Shahsavari S, Manickavasagam J. A Case of Human Papillomavirus-positive Nasal Vestibule Squamous Cell Carcinoma. Int J Head Neck Surg 2023; 14 (2):36-39.
A 68-year-old man with a history of recurrent right epistaxis was diagnosed with a case of human papillomavirus (HPV)-positive nasal squamous cell carcinoma (SCC) on biopsy. A computed tomography (CT) scan revealed an infiltrative right nasal mass with surrounding bone destruction. The tumor was described to be invading the right nasal alar, medial rectus, and lacrimal punctum. Further involvement of the right maxillary nasal process was noted. Immunohistochemistry revealed a lesion with a surface epithelium exhibiting high-grade cytonuclear atypia and conferring positivity for p16 and HPV. After deliberation with the local head and neck multidisciplinary team (MDT), it was decided this case was not fit for surgical excision due to tumor involvement of the eye. The patient was offered a combination of radiotherapy with chemotherapy and responded well to treatment. HPV is prevalent in tumors of the sinonasal (SN) tract although, at present, limited information is available on the clinical profile of individuals diagnosed with this condition. We report a peculiar case of HPV-positive nasal SCC and evaluate the current understanding of the disease within the literature.
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