Citation Information :
Ayyaswamy A, Lakshmanan S, Manimaran V, Iyyasamy B. A Case Report on Paranasal Synovial Sarcoma: Rare Tumor at an Uncommon Location. Int J Head Neck Surg 2023; 14 (3):51-53.
Background: Synovial sarcoma of paranasal sinuses (PNSs) is very rare. It is a high-grade malignant tumor of soft tissues. It arises from mesenchymal cells and not from the synovial membrane. The head and neck is the second most common site for synovial sarcoma after the extremities.
Case description: A 72-year-old male with left-sided nasal obstruction, epistaxis, loss of smell, and left eye proptosis. On anterior rhinoscopy, a proliferative mass was seen occupying the left nasal cavity and extending up to the floor of the nose. The mass was nonreducible, bled on touch, and friable on probing. Diagnostic nasal endoscopy showed a friable proliferative mass in the left nasal cavity extending up to the floor of the nose. In contrast Enhanced computed tomography (CECT) of the PNS, a heterogeneous soft tissue density with the central nonenhancing area is noted. Intraorbital extension showed erosion of the medial and inferior wall of the orbit and loss of fat plane with no involvement of orbital apex. An endoscopic biopsy of the sinonasal mass showed a spindle cell variant of synovial sarcoma which was confirmed by immunohistochemistry. The patient underwent concurrent radiotherapy as a treatment modality.
Conclusion: The clinical presentation and management of synovial sarcoma of PNS are presented in this case report, along with a literature review. Though it commonly affects young individuals, it can also affect the elderly.
Harb WJ, Luna MA, Patel SR, et al. Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. Head Neck 2007;29(8):731–740. DOI: 10.1002/hed.20564
Carrillo R, Rodriguez-Peralto JL, Batsakis JG. Synovial sarcomas of the head and neck. Ann Otol Rhinol Laryngol 1992;101(4):367–370. DOI: 10.1177/000348949210100415
Sturgis EM, Potter BO. Sarcomas of the head and neck region. Curr Opin Oncol 2003;15(3):239–252. DOI: 10.1097/00001622-200305000-00011
Saito S, Ozawa H, Ikari Y, et al. Synovial sarcoma of the maxillary sinus: an extremely rare case with excellent response to chemotherapy. Onco Targets ther 2018;11:483–488. DOI: 10.2147/OTT.S151473
Eilber FC, Dry SM. Diagnosis and management of synovial sarcoma. J Surg Oncol 2008;97(4):314–320. DOI: 10.1002/jso.20974
Thway K, Fisher C. Synovial sarcoma: defining features and diagnostic evolution. Ann Diagn Pathol 2014;18(6):369–380. DOI: 10.1016/j.anndiagpath.2014.09.002
Gallia GL, Sciubba DM, Hann CL, et al. Synovial sarcoma of the frontal sinus: case report. J Neurosurg 2005;103(6):1077–1080. DOI: 10.3171/jns.2005.103.6.1077
Jiang X, Huang Q, Tang J, et al. Monophasic epithelial synovial sarcoma accompanied by an inverted papilloma in the sphenoid sinus. Case Rep Med 2012;2012:379720. DOI: 10.1155/2012/379720
Gore MR. Treatment, outcomes, and demographics in sinonasal sarcoma: a systematic review of the literature. BMC Ear Nose Throat Disord 2018;18(1):4. DOI: 10.1186/s12901-018-0052-5
Dhiman S, Negi S, Moudgil S, et al. Synovial sarcoma of ethmoidal sinus. Surgery J (N Y) 2021;7(3):e195–e198. DOI: 10.1055/s-0041-1731634
Wu Y, Bi W, Han G, et al. Influence of neoadjuvant chemotherapy on prognosis of patients with synovial sarcoma. World J Surg Oncol 2017;15(1):101. DOI: 10.1186/s12957-017-1165-9
Martin E, Radomski S, Harley E. Sarcomas of the paranasal sinuses: an analysis of the SEER database. Laryngoscope Investig Otolaryngol 2019;4(1):70–75. DOI: 10.1002/lio2.245