International Journal of Head and Neck Surgery

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VOLUME 2 , ISSUE 1 ( January-April, 2011 ) > List of Articles


Primary Small Cell Carcinoma of Nasal Cavity Presenting as Unilateral Blindness

Ashutosh Chauhan, NC Chakarborty, Pramod Nath, Manomoy Ganguly

Citation Information : Chauhan A, Chakarborty N, Nath P, Ganguly M. Primary Small Cell Carcinoma of Nasal Cavity Presenting as Unilateral Blindness. Int J Head Neck Surg 2011; 2 (1):61-63.

DOI: 10.5005/jp-journals-10001-1050

Published Online: 01-08-2012

Copyright Statement:  Copyright © 2011; The Author(s).


Primary sinonasal small cell carcinomas are extremely rare lesions. We present a case of 29-year-old male patient, who initially presented with recurrent right sided nasal obstruction and occasional epistaxis, but came to medical attention when he developed progressive deterioration of vision in ipsilateral eye. Radiological examination showed a tumor with epicenter in right nasal cavity with extensive local infiltration. The histopathology picture and immunohistochemistry profile of the tumor showed it to be a primary small cell neuroendocrine tumor. Extensive imaging studies revealed no other site of primary. He was treated with induction chemotherapy followed by concomitant chemoradiotherapy. Complete clinical response was seen and the patient has been disease free since last 20 months. The report discusses the diagnostic criteria which differentiates this extremely rare but aggressive tumor from a much more common and more indolent tumor, esthesioneuroblastoma.

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  1. The pathology of extra pulmonary small cell carcinoma. Semin Oncol 2007;34:30-38.
  2. Sinonasal neuroendocrine carcinoma: A case report. Ear Nose Throat J 2008;87:280-82,293.
  3. Blindness: A sequela of sinonasal small cell neuroendocrine carcinoma. Ear Nose Throat J 2004;83: 530-32.
  4. EB Neuroendocrine carcinoma of the sphenoid sinus: A case report. Rhinology 2001;39:52-54.
  5. Small cell carcinoma of the head and neck: The university of Miami experience. Int J Radiat Oncol Biol Phys 2009;74:477-81.
  6. Olfactory neuroblastoma and other round cell lesions of the sinonasal region. Mod Pathol 1996;9:658-63.
  7. Esthesioneuroblastoma: A meta-analysis and review. Lancet Oncol 2001;2:683-90.
  8. Small cell neuroendocrine carcinoma of the sinonasal region: A proposal of a case. Br J Oral Maxillofac Surg 2007;45: 676-78.
  9. Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses. J Laryngol Otol 2006;120:289-97.
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