International Journal of Head and Neck Surgery

Register      Login

VOLUME 2 , ISSUE 3 ( September-December, 2011 ) > List of Articles


Alterations in the Serum Lipid Profile in Patients with Oral Cancer, Oral Precancerous Lesions/Conditions associated with the Habit of Tobacco Consumption

Sonal Vahanwala, Sandeep Pagare, Shilpa Dua

Citation Information : Vahanwala S, Pagare S, Dua S. Alterations in the Serum Lipid Profile in Patients with Oral Cancer, Oral Precancerous Lesions/Conditions associated with the Habit of Tobacco Consumption. Int J Head Neck Surg 2011; 2 (3):130-133.

DOI: 10.5005/jp-journals-10001-1067

Published Online: 01-12-2012

Copyright Statement:  Copyright © 2011; The Author(s).


The changes in lipid profile have long been associated with cancer because lipids play a key role in maintenance of cell integrity. Lipids are the major cell membrane components essential for various biological functions including cell growth and division of normal and malignant tissues. Lower blood lipids have been associated with the etiology of breast and colorectal cancer, and relation has also been reported between low cholesterol and increased risk of cancer occurrence and mortality.

The present study was designed to evaluate the serum lipid profile in patients with oral precancerous lesion/condition and squamous cell carcinoma to see whether there are any alterations in the lipid levels during the pathogenesis of these lesions and also to evaluate significance of lipid profile as biochemical marker, if any.

PDF Share
  1. A global view of epidemiology of oral cancer. In risk makers for oral disease, Johnson NW, (ed), University Press, Cambridge 1991;2:2-27.
  2. Carcinoma incidence in five continents. IARC, Lyon 1997;7:143.
  3. Estimates of the world wide incidence of eighteenx major cancers in 1985. Int J of Can 1993;54:594-606.
  4. Alterations in plasma lipid profile pattern in head and neck cancer and oral precancerous conditions. Ind J Cancer 2004;41(1):25-31.
  5. Textbook of oral pathology (2nd edn). Oxford University Press No 138.
  6. Oral precancerous lesions and conditions of tropical interest. In: Prabhu SR, Wilson DF (Eds). Oral diseases in tropics, Delhi 1993;402-24.
  7. Textbook of oral and maxillofacial pathology. (2nd edn) pp. 359.
  8. Burket's oral medicine diagnosis and treatment (9th edn). JB Lipppincot Co: 1994.
  9. Oral cancer among patients under the age of 35 years. 2001;47(3):171-76.
  10. Serum lipoprotein levels in patients with cancer. Can Res 1972;32:1756-60.
  11. The possible prognostic usefulness of assessing serum proteins and cholesterol in malignancy. Can Res 1975;35:1223-29.
  12. Serum antioxidative levels and lipid peroxidation in gastric carcinoma patients. Cancer Letters 1999;136:89-93.
  13. Site specific analysis of total serum cholesterol and incident of cancer in the national health and nutrition examination survey I epidemiologic follow-up study. Can Res 1988;48:452-58.
  14. Prospective study of serum cholesterol and site-specific cancers. J Clin Epidemiol 1992;45:287-92.
  15. Hypocho-lesterolemia in malignancy due to elevated low-density lipoprotein receptor activity in tumor cells. Evidence from studies in patients with Leukemia. Lancet 1985;2:1150-54.
  16. Altered pattern of lipid metabolism in patients with lung cancer. Oncology 1992;49: 436-41.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.