International Journal of Head and Neck Surgery

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VOLUME 6 , ISSUE 4 ( October-December, 2015 ) > List of Articles


Biopotential Assessment—An Alternative in Oral Squamous Cell Carcinoma Diagnostics: A Study

Soumyo Mukherji, Sonal P Vahanwala, Arvind Dhawangale, Sourabh Agrawal

Citation Information : Mukherji S, Vahanwala SP, Dhawangale A, Agrawal S. Biopotential Assessment—An Alternative in Oral Squamous Cell Carcinoma Diagnostics: A Study. Int J Head Neck Surg 2015; 6 (4):168-174.

DOI: 10.5005/jp-journals-10001-1248

Published Online: 01-03-2017

Copyright Statement:  Copyright © 2015; The Author(s).



The aim of this study was to ascertain the relation between surface electrical potential and the presence of cancer in the buccal mucosa and their correlation.

Materials and methods

A device was designed to measure the skin potentials on the face, and various head and neck carcinomas can be detected in a noninvasive way. The present study is a case control study in the ratio 1:1, comprising two groups of 10 individuals each. The two distinct groups of the study are as follows:

1. Normal subjects group consisting of individuals with no habit of tobacco, with the absence of any lesion active or passive on the skin or buccal mucosa.

2. Cancer patients group consisting of individuals attending the head and neck services at the Tata Memorial Hospital, Mumbai, with the habit of tobacco consumption and having a lesion on the buccal mucosa with biopsy confirming diagnosis of squamous cell carcinoma (SCC).


Sites of SCC were significantly electropositive compared with control sites in normal tissue. But noncancerous lesions yielded no potential difference between the lesion and control sites.


The skin surface potential values are maintained in an individual with no cancerogenesis, whereas in oral squamous cell carcinoma (OSCC) the lesion values are more electropositive than the surrounding areas. This can be used to detect OSCC.

Significance: The device designed is patient-compliant and can be used in cancers of breast, colon, etc. More research work is recommended on skin surface potentials.

How to cite this article

Vahanwala SP, Mukherji S, Dhawangale A, Agrawal S. Biopotential Assessment—An Alternative in Oral Squamous Cell Carcinoma Diagnostics: A Study. Int J Head Neck Surg 2015;6(4):168-174.

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  1. Bioelectric potentials. Their source, recording and significance IEEE. Trans Biomed Eng 1984 Dec; BME-31(12):863-868.
  2. Biopotential electrodes. Chapter 48.
  3. Diagnosis and cure of the Wolff-Parkinson-White syndrome or paroxysmal supraventricular tachycardias during a single electrophysiologic test. New Engl J Med 1991 Jun;324(23):1612-1618.
  4. Radical presence: teaching as contemplative practice. Boynton (MN): Cook Publishers; 1998.
  5. Effect of the KCNQ potassium channel opener retigabine on single KCNQ2/3 channels expressed in CHO cells. J Physiol 2003 May 15;549(1):57-63.
  6. Rotational diffusion of rhodopsin in the visual receptor membrane. Nature 1972 Mar 15;236(63):39-43.
  7. Chemical differences in hop varieties vs susceptibility to the two spotted spider mite. Environ Entomol 1975 Oct;4(5):697-700.
  8. Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature 1990 Jan;343(6256):341-346.
  9. Environmental assessments for strategic planning. New Directions Inst Res 1981;1981(31):5-15.
  10. Nuclear magnetic resonance transverse relaxation times of water protons in skeletal muscle. Biophys J 1974 Aug;14(8):583-606.
  11. Electropotential measurements as a new diagnostic modality for breast cancer. Lancet 1998 Aug;352(9125):359-363.
  12. Electropotential evaluation as a new technique for diagnosing breast lesions. Eur J Radiol 1997 Jan;24(1):33-38.
  13. Principles and practice of mass screening for disease. Public screening paper. 34. 1968
  14. Electrical potential measurements in human breast cancer and benign lesions. Tumor Biol 1994;15(3):147-152.
  15. Ionic channels of excitable membranes. Sunderland: Sinauer; 1984.
  16. A parotid fluid collection device with improved stability characteristics. J Oral Ther Pharmacol 1967 Sep;4(2):93-97.
  17. World-wide-web server with delayed resource-binding for resource-based load balancing on a distributed resource multi-node network. US patent. 5,774,660. 1998 Jun 30.
  18. Evaluation of the efficiency of biofield diagnostic system in breast cancer detection using clinical study result and classifiers. J Med Syst 2012 Feb;36(1):15-24.
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