International Journal of Head and Neck Surgery

Register      Login

VOLUME 7 , ISSUE 4 ( October-December, 2016 ) > List of Articles

RESEARCH ARTICLE

An 8-year Pattern of Orofacial Sarcoma from the National Referral Hospital in United Republic of Tanzania

Citation Information : An 8-year Pattern of Orofacial Sarcoma from the National Referral Hospital in United Republic of Tanzania. Int J Head Neck Surg 2016; 7 (4):207-212.

DOI: 10.5005/jp-journals-10001-1290

Published Online: 00-12-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim:

This study aimed at evaluating the pattern of head and neck sarcomas among patients treated at Muhimbili National Hospital, Tanzania.

Background

Sarcomas of the head and neck are very rare, representing only 1% of all primary tumors arising within the head and neck region and accounting for 4 to 10% of all sarcomas, with more than 50 distinct existing histologic subtypes.

Materials and methods

It was a retrospective study whereby histological results of the lesions arising from oral and maxillofacial region between 2008 and 2016 were analyzed. Patient's demographic data, histopathological diagnosis, and the type of sarcoma were recorded. The lesions were broadly grouped as soft and hard tissue sarcomas (HTSs). Data analysis was done using Statistical Package for the Social Sciences version 19 computer program.

Results

Sarcomas accounted for 7% of all lesions occurring in orofacial region. Male to female ratio was 1:1.4. The age ranged from 3 to 81 years, mean age being 33 ± 16 years. The most affected age groups were of 30 to 39 followed by 20 to 29 years. Approximately half of the patients were aged below 30 years and three quarters below 40 years. Kaposi's sarcoma (KS) and rhabdomyosarcoma were the most common soft tissue sarcoma (STS), while osteosarcoma and chondrosarcoma were the commonest HTS.

Conclusion

The analysis demonstrated that the head and neck sarcomas are a very rare group of neoplasm, with approximately 20 cases per year. The STSs are more common than the HTSs, while KS is the most common, followed by osteosarcoma and rhabdomyosarcoma. Generally, patients less than 40 years of age are the mostly affected, with a slightly higher female predominance.

Clinical significance

By contributing to the identification of the incidence of sarcomas at a tertiary hospital in Tanzania, this study promotes scientific understanding of pattern of occurrence and underscores the necessity of early detection of sarcomas, since the affected are young individuals.

How to cite this article

Moshy JR, Owibingire SS, Sohal KS. An 8-year Pattern of Orofacial Sarcoma from the National Referral Hospital in United Republic of Tanzania. Int J Head Neck Surg 2016;7(4):207-212.


PDF Share
  1. Sarcomas of the oral and maxillofacial region: a review of 32 cases in 25 years. Clin Oral Investig 2004 Jun;8(2):52-55.
  2. Sarcomas of the head and neck. Surg Oncol Clin N Am 2003 Apr;12(2):379-417.
  3. Update in management of head and neck sarcoma. Curr Opin Oncol 2004 Jul;16(4):333-341.
  4. Sarcoma epidemiology and etiology: potential environmental and genetic factors. Surg Clin North Am 2008 Jun;88(3):451-481.
  5. The epidemiology of sarcoma. Clin Sarcoma Res 2012 Oct;2:14-16.
  6. Outcome in adult patients with head and neck sarcomas – a 10-year analysis. J Surg Oncol 2010 Aug;102(2):170-174.
  7. Musculoskeletal cancer surgery treatment of sarcomas and allied diseases. Dordrecht: Kluwer Academic Publishers; 2001. p. 4.
  8. Two hundred and forty six tumours and tumour-like conditions of the jaw seen in Zaria, Nigeria. Ann Afr Med 2002 Dec;1(2):72-78.
  9. Soft tissue sarcoma of infants and children; a clinicopathologic study of 135 cases. Mayo Clin Proc 1968 May;43(5):313-326.
  10. Sarcomas of the oral and maxillofacial region: a review of 88 cases in Zimbabwe. Br J Oral Maxillofac Surg 2007 Jun;45(4):317-318.
  11. Head and neck sarcoma in Tehran. Tehran Univ Dent J 1999;75(3):250-257.
  12. Epidemiology of the sarcomas of the jaws in a Peruvian population. Med Oral Patol Oral Cir Bucal 2012 Mar;17(2):e201-e205.
  13. Epidemiological evaluation of head and neck sarcomas in Iran (the study of 105 cases over 13 years). Iran J Cancer Prev 2015 Aug;8(4):e3432.
  14. Changing incidence of oral and maxillofacial tumours in East Java, Indonesia, 1987-1992. Part 2: malignant tumours. Br J Oral Maxillofac Surg 2001 Dec;39(6):460-464.
  15. Prognostic factors in adult soft tissue sarcomas of the head and neck: a single-centre experience. Oral Oncol 2006 Aug;42(7):703-709.
  16. Clinicopathological study of patients with head and neck sarcomas. Braz J Otorhinolaryngol 2011 Jun;77(3):385-390.
  17. Head and neck sarcoma: analysis of 29 cases. Eur Ann Otorhinolaryngol Head Neck Dis 2014 Apr;131(2):83-86.
  18. Gathece L. Clinico histopathologic types of maxillofacial malignancies with emphasis on sarcomas: a 10-year review. East Afr Med J 2011 Feb;88(2):39-45.
  19. Maxillofacial sarcomas in Nigeria. Ann Afr Med 2005 Mar;4(1):23-30.
  20. Sarcomas of the head and neck region. East Afr Med J 2000 May;77(5):256-259.
  21. Oral Kaposis’ sarcoma: a clinicopathological study from South Africa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003 Dec;96(6):701-710.
  22. Prevalence and classification of HIV-associated oral lesions. Oral Dis 2002 Jul;8 (Suppl 2): 98-109.
  23. Detection of human herpesvirus 8 DNA in serum from blood donors with HHV-8 antibodies indicates possible bloodborne virus transmission. J Med Virol 2002 Oct;68(2):264-267.
  24. Oral Kaposi's sarcoma: HIV, HHV-8 association, immunopathology and clinical aspects. Oncol Rep 2007 Jun:17(6);1291-1299.
  25. Using epidemiology and genomics to understand osteosarcoma etiology. Sarcoma 2011 Jan;2011:548151.
  26. Osteosarcoma of the jaws: a review of literature and a case report on synchronous multicentric osteosarcomas. World J Surg Oncol 2012 Nov;10:240.
  27. Rhabdomyosarcoma: review of the Children's Oncology Group (COG) Soft-Tissue Sarcoma Committee experience and rationale for current COG studies. Pediatr Blood Cancer 2012 Jul;59(1):5-10.
  28. Trends in childhood rhabdomyosarcoma incidence and survival in the United States (1975–2005). Cancer 2009 Sep;115(18):4218-4226.
  29. Chondrosarcoma of the head and neck. Yonsei Med J 2005 Apr;46(2):228-232.
  30. Head and neck chondrosarcoma: analysis of 16 cases. Br J Oral Maxillofac Surg 2009 Oct;47(7):555-557.
  31. Soft tissue sarcoma- a new approach to diagnosis and classification. Curr Probl Cancer 2013 Mar-Apr;37(2):45-61.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.