Citation Information :
Bhardwaj A, Gupta S, Moirangthem R, Anant A, Bharadwaj N. Intralesional Bleomycin as Therapeutic Modality for Low-flow Venous Malformations: Treatment on Outpatient Basis. Int J Head Neck Surg 2017; 8 (3):112-117.
Introduction: Venous malformations (VMs) are the most common type of vascular malformations in the human body, most commonly involving head and neck region. Intralesional sclerotherapy with and without image guidance has been used as therapeutic modality with effective outcome. The aim of our study was to evaluate the result of intralesional bleomycin injection without image guidance in low-flow VMs of head and neck.
Materials and methods: This was an observational study conducted in the Department of Otorhinolaryngology, Vardhman Mahavir Medical College (VMMC) and Safdarjung Hospital, New Delhi, India, between September 2014 and November 2016. Fifty-five patients, 27 males and 28 females, diagnosed as low-flow VM based on clinical features and ultrasound, were treated with multiple doses of intralesional bleomycin injection at 3 weeks interval on an outpatient basis. Reduction in size, occurrence of adverse reactions, and recurrence were observed and recorded. Outcomes were graded as complete reduction (>90% reduction), considerable reduction (50–90% reduction), partial reduction (20–50% reduction), and no change (<20% reduction). Treatment was considered successful in cases of complete or considerable reduction.
Results: A total of 50 (90.9%) patients were successfully treated. Complications were minor and included small skin ulcer in 4 (7.2%) and hyperpigmentation in 3 (5.4%) patients. No recurrence was noted.
Conclusion: Intralesional bleomycin sclerotherapy serves as an excellent treatment modality for low-flow VMs. Such patients can be treated on an outpatient basis without fear of any major complication.
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