International Journal of Head and Neck Surgery

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VOLUME 9 , ISSUE 1 ( January-March, 2018 ) > List of Articles

REVIEW ARTICLE

Novel Treatments for Chronic Rhinosinusitis

Claire Hopkins, Abigail Walker

Keywords : Monoclonal antibodies, Nasal polyposis, Robotic surgery, Sinus,Chronic rhinosinusitis

Citation Information : Hopkins C, Walker A. Novel Treatments for Chronic Rhinosinusitis. Int J Head Neck Surg 2018; 9 (1):15-20.

DOI: 10.5005/jp-journals-10001-1331

License: CC BY-NC 4.0

Published Online: 00-03-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

As we move into the era of personalized medicine, there has been considerable progress made toward an increasingly sophisticated understanding of chronic rhinosinusitis. Precise understanding of the pathophysiology and natural history of the disease has unlocked a novel range of therapeutic options, both medical and surgical. This literature review aims to appraise some of these developments, including the utility of monoclonal antibodies, office based procedures such as balloon sinuplasty and steroid-eluting stents, and adjuncts to surgery such as image guidance. In reviewing the evidence for these novel interventions we aim to provide an insight to the tools which may become commonplace in the arsenal of the rhinologist of the future.


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  1. Hastan D, Fokkens W, Bachert C, Newson RB, Bislimovska J, Bockelbrink A, Bousquet PJ, Brozek G, Bruno A, Dahlen SE, et al. Chronic rhinosinusitis in Europe. an underestimated disease. A GA2LEN study. Allergy 2011 Sep;66(9):1216-1223.
  2. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. Rhinology 2012 Mar;50(1):1-12.
  3. Akdis CA, Bachert C, Cingi C, Dykewicz MS, Hellings PW, Naclerio RM, Schleimer RP, Ledford D. Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European academy of allergy and clinical immunology and the American academy of allergy, asthma & immunology. J Allergy Clin Immunol 2013 Jun;131(6):1479-1490.
  4. Bachert C, Holtappels G. Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options. GMS Curr Top Otorhinolaryngol Head Neck Surg 2015 Dec;14:Doc09.
  5. Stevens WW, Schleimer RP, Chandra RK, Peters AT. Biology of nasal polyposis. J Allergy Clin Immunol 2014 May;133(5):1503. e1-1503.e4.
  6. Zhang N, Van Zele T, Perez-Novo C, Van Bruaene N, Holtappels G, DeRuyck N, Van Cauwenberge P, Bachert C. Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease. J Allergy Clin Immunol 2008 Nov;122(5):961-968.
  7. Boase S, Foreman A, Cleland E, Tan L, Melton-Kreft R, Pant H, Hu FZ, Ehrlich GD, Wormald PJ. The microbiome of chronic rhinosinusitis: culture, molecular diagnostics and biofilm detection. BMC Infect Dis 2013 May;13(1):210.
  8. Soyka MB, Wawrzyniak P, Eiwegger T, Holzmann D, Treis A, Wanke K, Kast JI, Akdis CA. Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-ƒÁ and IL-4. J Allergy Clin Immunol 2012 Nov;130(5):1087. e10-1096.e10.
  9. Bachert C, Mannent L, Naclerio RM, Mullol J, Ferguson BJ, Gevaert P, Hellings P, Jiao L, Wang L, Evans RR, et al. Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial. JAMA 2016 Feb;315(5):469-479.
  10. Gevaert P, Calus L, Van Zele T, Blomme K, De Ruyck N, Bauters W, Hellings P, Brusselle G, De Bacquer D, van Cauwenberge P, et al. Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma. J Allergy Clin Immunol 2013 Jan;131(1):110.e1-116.e1.
  11. Gevaert P, Van Bruaene N, Cattaert T, Van Steen K, Van Zele T, Acke F, De Ruyck N, Blomme K, Sousa AR, Marshall RP, et al. Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis. J Allergy Clin Immunol 2011 Nov;128(5):989-995.e1-e8.
  12. National Institute of Clinical Excellence. Omalizumab for treating severe persistent allergic asthma: costing statement. London: NICE Technology Appraisal Guidance; 2013. p. 278.
  13. Lee M, Kim DW, Shin HW. Targeting IL-25 as a novel therapy in chronic rhinosinusitis with nasal polyps. Curr Opin Allergy Clin Immunol 2017 Feb;17(1):17-22.
  14. Shin HW, Kim DK, Park MH, Eun KM, Lee M, So D, Kong IG, Mo JH, Yang MS, Jin HR, et al. IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis. J Allergy Clin Immunol 2015 Jun;135(6):1476.e7-1485.e7.
  15. Mulligan JK, White DR, Wang EW, Sansoni SR, Moses H, Yawn RJ, Wagner C, Casey SE, Mulligan RM, Schlosser RJ. Vitamin D3 deficiency increases sinus mucosa dendritic cells in pediatric chronic rhinosinusitis with nasal polyps. Otolaryngol Head Neck Surg 2012 Oct;147(4):773-781.
  16. Stokes PJ, Rimmer J. The relationship between serum vitamin D and chronic rhinosinusitis: a systematic review. Am J Rhinol Allergy 2016 Jan-Feb;30(1):23-28.
  17. Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017 Feb;356:i6583.
  18. Martineau AR, Cates CJ, Urashima M, Jensen M, Griffiths AP, Nurmatov U, Sheikh A, Griffiths CJ. S5 Vitamin d for the management of asthma: cochrane systematic review and meta-analysis. BMJ 2016 Dec;71(Suppl 3):A1-A6.
  19. Van Crombruggen K, Zhang N, Gevaert P, Tomassen P, Bachert C. Pathogenesis of chronic rhinosinusitis: inflammation. J Allergy Clin Immunol 2011 Oct;128(4):728-732.
  20. Derycke L, Eyerich S, Van Crombruggen K, Pérez-Novo C, Holtappels G, Deruyck N, Gevaert P, Bachert C. Mixed T helper cell signatures in chronic rhinosinusitis with and without polyps. PloS One 2014 Jun;9(6):e97581.
  21. Calixto NE, Gregg-Jaymes T, Liang J, Jiang N. Sinus procedures in the medicare population from 2000 to 2014: a recent balloon sinuplasty explosion. Laryngoscope 2017 Sep;127(9):1976-1982.
  22. Bizaki AJ, Taulu R, Numminen J, Rautiainen M. Quality of life after endoscopic sinus surgery or balloon sinuplasty: a randomized clinical study. Rhinology 2014 Dec;52(4): 300-305.
  23. Chandra RK, Kern RC, Cutler JL, Welch KC, Russell PT. REMODEL larger cohort with long-term outcomes and metaanalysis of standalone balloon dilation studies. Laryngoscope 2016 Jan;126(1):44-50.
  24. Koskinen A, Myller J, Mattila P, Penttilä M, Silvola J, Alastalo I, Huhtala H, Hytönen M, Toppila-Salmi S. Long-term followup after ESS and balloon sinuplasty: comparison of symptom reduction and patient satisfaction. Acta Otolaryngol 2016 Feb;136(5):532-536.
  25. Catalano P, Hester J, Mandrusov E. Osmotic self-expanding dilation technology for treatment of sinusitis: the Vent-Os sinus dilation system. Expert Rev Med Devices 2015 Jan;12(1): 19-24.
  26. Gan EC, Habib AR, Hathorn I, Javer AR. The efficacy and safety of an office-based polypectomy with a vacuumpowered microdebrider. Int Forum Allergy Rhinol 2013 Nov;3(11):890-895.
  27. Li PF, Downie D, Hwang PH. Controlled steroid delivery via bioabsorbable stent: safety and performance in a rabbit model. Am J Rhinol Allergy 2009 Nov-Dec;23(6):591-596.
  28. Janisiewicz A, Lee JT. In-office use of a steroid-eluting implant for maintenance of frontal ostial patency after revision sinus surgery. Allergy Rhinol (Providence) 2015 Spring;6(1):e68-e75.
  29. Lavigne F, Miller SK, Gould AR, Lanier BJ, Romett JL. Steroideluting sinus implant for in-office treatment of recurrent nasal polyposis: a prospective, multicenter study. Int Forum Allergy Rhinol 2014 May;4(5):381-389.
  30. Matheny KE, Carter KB, Tseng EY, Fong KJ. Safety, feasibility, and efficacy of placement of steroid-eluting bioabsorbable sinus implants in the office setting: a prospective case series. Int Forum Allergy Rhinol 2014 Oct;4(10):808-815.
  31. Mahboubi H, Bhandarkar ND. Trends of ambulatory sinus surgery for chronic rhinosinusitis. Int Forum Allergy Rhinol 2015 Apr;5(4):318-325.
  32. American Academy Otolaryngology–Head and Neck Surgery. Position statement: intra-operative use of computer aided surgery. Alexandria (VA): American Academy Otolaryngology–Head and Neck Surgery; 2014. [cited 2016 Aug 20]. Available from: http://www.entnet.org/content/intra-operative-use-computer-aided-surgery.
  33. Justice JM, Orlandi RR. An update on attitudes and use of image-guided surgery. Int Forum Allergy Rhinol 2012 Mar-Apr;2(2):155-159.
  34. Ramakrishnan VR, Orlandi RR, Citardi MJ, Smith TL, Fried MP, Kingdom TT. The use of image-guided surgery in endoscopic sinus surgery: an evidence-based review with recommendations. Int Forum Allergy Rhinol 2013 Mar;3(3):236-241.
  35. Eloy JA, Svider PF, D'Aguillo CM, Baredes S, Setzen M, Folbe AJ. Image-guidance in endoscopic sinus surgery: is it associated with decreased medicolegal liability? Int Forum Allergy Rhinol 2013 Dec;3(12):980-985.
  36. Besharati Tabrizi L, Mahvash M. Augmented realityguided neurosurgery: accuracy and intraoperative application of an image projection technique. J Neurosurg 2015 Jul;123(1):206-211.
  37. Meola A, Cutolo F, Carbone M, Cagnazzo F, Ferrari M, Ferrari V. Augmented reality in neurosurgery: a systematic review. Neurosurg Rev 2017 Oct;40(4):537-548.
  38. Felisati G, Pipolo C, Maccari A, Cardia A, Revay M, Lasio GB. Transnasal 3D endoscopic skull base surgery: questionnaire-based analysis of the learning curve in 52 procedures. Eur Arch Otorhinolaryngol 2013 Aug;270(8):2249-2253.
  39. Manes RP, Barnett S, Batra PS. Utility of novel 3-dimensional stereoscopic vision system for endoscopic sinonasal and skull-base surgery. Int Forum Allergy Rhinol 2011 May-Jun;1(3):191-197.
  40. Kupferman M, DeMonte F, Holsinger FC, Hanna E. Transantral robotic access to the pituitary gland. Otolaryngol Head Neck Surg 2009 Sep;141(3):413-415.
  41. Rudmik L, Holy CE, Smith TL. Geographic variation of endoscopic sinus surgery in the United States. Laryngoscope 2015 Aug;125(8):1772-1778.
  42. Pynnonen MA, Davis MM. Extent of sinus surgery, 2000 to 2009: a population-based study. Laryngoscope 2014 Apr;124(4):820-825.
  43. DeConde AS, Suh JD, Mace JC, Alt JA, Smith TL. Outcomes of complete vs targeted approaches to endoscopic sinus surgery. Int Forum Allergy Rhinol 2015 Aug;5(8):691-700.
  44. Naidoo Y, Bassiouni A, Keen M, Wormald P. Risk factors and outcomes for primary, revision, and modified lothrop (Draf III) frontal sinus surgery. Int Forum Allergy Rhinol 2013 May;3(5):412-417.
  45. AlQahtani A, Bignami M, Terranova P, Digilio E, Basilico F, Abdulrahman S, Castelnuovo P. Newly designed doublevascularized nasoseptal flap to prevent restenosis after endoscopic modified lothrop procedure (Draf III): laboratory investigation. Eur Arch Otorhinolaryngol 2014 Nov;271(11): 2951-2955.
  46. Illing EA, Cho DY, Riley KO, Woodworth BA. Draf III mucosal graft technique: long-term results. Int Forum Allergy Rhinol 2016 May;6(5):514-517.
  47. Chin D, Snidvongs K, Kalish L, Sacks R, Harvey RJ. The outside-in approach to the modified endoscopic lothrop procedure. Laryngoscope 2012 Aug;122(8):1661-1669.
  48. Knisely A, Barham HP, Harvey RJ, Sacks R. Outside-in frontal drill-out: how I do it. Am J Rhinol Allergy 2015 Sep-Oct;29(5):397-400.
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