This review will provide a comprehensive overview of the current management of oropharyngeal cancer. The contemporary literature, as it relates to diagnosis and management, will be summarized and the existing limitations of our knowledge will be highlighted. Research questions which need to be addressed as a matter of urgency will be listed and ongoing clinical trials designed to fill the current gaps in our knowledge will be briefly described.
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Ang KK, Zhang Q, Rosenthal DI, Nguyen-Tan PF, Sherman EJ, Weber RS, et al. Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol 2014 Sep;32(27):2940-2950.
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Paleri V, Urbano TG, Mehanna H, Repanos C, Lancaster J, Roques T, et al. Management of neck metastases in head and neck cancer: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol 2016 May;130(S2):S161-S169.
Owadally W, Hurt C, Timmins H, Parsons E, Townsend S, Patterson J, et al. PATHOS: a phase II/III trial of riskstratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV) positive oropharyngeal cancer. BMC Cancer 2015 Aug;15:602.
Gillison ML, Zhang Q, Jordan R, Xiao W, Westra WH, Trotti A, et al. Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer. J Clin Oncol 2012 Jun;30(17):2102-2111.
Ferris RL, Blumenschein G, Fayette J, Guigay J, Dimitrios Colevas A, Licitra L, et al. Nivolumab for recurrent squamouscell carcinoma of the head and neck. N Engl J Med 2016 Nov;375:1856-1867.13 04 2018.