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VOLUME 10 , ISSUE 3 ( July-September, 2019 ) > List of Articles

Special Issue 3: Invited Article

Role of Obstructive Sleep Apnea in Cognitive Impairment

Pamela Barletta, Alexandre R Abreu, Alberto R Ramos, Salim I Dib, Carlos Torre, Alejandro D Chediak

Keywords : Cognitive, Comorbidities, Dementia, Obstructive sleep apnea

Citation Information : Barletta P, Abreu AR, Ramos AR, Dib SI, Torre C, Chediak AD. Role of Obstructive Sleep Apnea in Cognitive Impairment. Int J Head Neck Surg 2019; 10 (3):57-61.

DOI: 10.5005/jp-journals-10001-1373

License: CC BY-NC 4.0

Published Online: 00-09-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder characterized by repetitive collapse of the upper airways leading to intermittent hypoxia and sleep disruption. Clinically relevant neurocognitive, metabolic and cardiovascular disease often occurs in OSA. Systemic hypertension, coronary artery disease, type 2 diabetes mellitus, cerebral vascular infarctions and atrial fibrillation are among the most often cited conditions with causal connections to OSA. Emerging science suggests that untreated and undertreated OSAs increase the risk of developing cognitive impairment, including vascular dementia and neurodegenerative disorders like Alzheimer\'s disease. As with OSA, cardiovascular disease and type 2 diabetes mellitus, the incidence of dementia increases with age. Given our rapidly aging population, dementia prevalence will significantly increase. The aim of this treatise is to review current literature linking OSA to dementia and explore putative mechanisms by which OSA might facilitate the development and progression of dementia.


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