International Journal of Head and Neck Surgery

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VOLUME 1 , ISSUE 2 ( May-August, 2010 ) > List of Articles

REVIEW ARTICLE

Strategies in Management of Oral Mucositis

Sonal Vahanwala, Sandeep Pagare

Citation Information : Vahanwala S, Pagare S. Strategies in Management of Oral Mucositis. Int J Head Neck Surg 2010; 1 (2):61-67.

DOI: 10.5005/jp-journals-10001-1012

Published Online: 01-12-2011

Copyright Statement:  Copyright © 2010; The Author(s).


Abstract

Oral mucositis is a clinically important and sometimes dose-limiting complication of Cancer Therapy. Mucositis lesions are painful, affect nutrition, quality of life and often hampers continuity of the treatment modality. The pathogenesis of oral mucositis is multifactorial and complex. This is a review paper which discusses various aspects a clinician should know in management of mucositis.


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  1. Curr opin otolaryngol Head Neck Surg 2007;15(2):123-29.
  2. Perspectives on cancer therapy induced mucosal injury: Pathogenesis, measurement, epidemiology and consequences for patients. Cancer 2004;100(s9):1995-2025.
  3. 0 (CTAE). Internet document. Available at: http://ctep.info.nih.gov/reporting/ctc_v30.html.
  4. Validation of a new scoring system for the assessment of Clinical trial research of oral mucositis induced by radiation or chemotherapy. Mucositis Study group. Cancer 1999;85(10):2103-13.
  5. ECOG common toxicity criteria. Available at: http://www.ecog.org/general/common_tox.html.
  6. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 2007;109(5):820-31.
  7. Antimicrobials, mucosal coating agents, anesthetics, analgesics and nutritional supplements for alimentary tract mucosits. Support Care Cancer 2006;14(6):528-32.
  8. Evaluation of an oral care protocol intervention in the prevention of chemotherapy- induced oral mucositis in paedriatric cancer patients. Eur J cancer 2001;37160;2056-63.
  9. Incidence of oral complications and application of a preventive protocol in children with acute leukemia. Spec Care Dentist 1998;18(5): 93-97.
  10. Prevention of oral mucositis in patients treated with high dose, chemotherapy and bone marrow transplantation: A randomized controlled trial comparing two protocols of dental care. Eur J cancer B Oral Oncol 1994;30B(2):93-97.
  11. The impact of mucositis on alpha-hemolytic streptococcal infection in patients undergoing autologous bone marrow transplantation for hematologic malignancies. Cancer 1998;82(11):2275-81.
  12. Effects of oral care on development of oral mucositis and micro-organisms in patients with esophageal cancer. Jpn J Infect Dis 2007;60(1):23-28.
  13. Efficacy of chlorhexidine and nystatin rinses in prevention of oral complications in leukemia and bone-marrow transplantation. Oral Surg Oral Med Oral Pathol 1992;73(6):682-89.
  14. Management of dentsl patients taking common hemostasis-altering medications. Oral Surg oral med Oral Patol Oral Radiol Endod 2007;103(3):Supp 1.
  15. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N engl J Med 2004;351(25):2590-98.
  16. Velafermin (CuraGen) Curr Opin Investig Drugs 2005;6(11):1179-85.
  17. Benzydamine HCL for prophylaxis of radiation- induced oral mucositis: Results from a multicentre, randomized, double-blind, placebocontrolled clinical trial. Cancer 2001;92(4):875-85.
  18. Standardised parenteral alanyl-glutamine dipeptide supplementation is not beneficial in autologous transplant patients: A randomized, double-blind, placebo controlled study. Bone marrow Transplant 2002;30(12):953-61.
  19. Reactive oxygen species, antioxidant mechanisms and serum cytokine levels in cancer patients; impact of an antioxidant treatment. J Environ Pathol Toxicol Oncol 2003;22(1):17-28.
  20. The role of alternative and natural agents, cryotherapy, and/or laser for management of alimentary mucositis. Support Care Cancer 2005;13(4):266-69.
  21. Diagnosis and management of oral mucositis. J Support Oncol 2007;59 suppl):13-21.
  22. Patient reports of complications of bone marrow transplantation. Support Care Centre 2000;33-39.
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