International Journal of Head and Neck Surgery

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VOLUME 4 , ISSUE 2 ( May-August, 2013 ) > List of Articles

RESEARCH ARTICLE

Prognostic and Predictive Impact of Ki-67 in Premalignant and Malignant Squamous Cell Lesions of Oral Cavity

SC Sharma, Veena Maheshwari, Varsha Narula, Sachin Verma, Anshu Jain, Kiran Alam

Citation Information : Sharma S, Maheshwari V, Narula V, Verma S, Jain A, Alam K. Prognostic and Predictive Impact of Ki-67 in Premalignant and Malignant Squamous Cell Lesions of Oral Cavity. Int J Head Neck Surg 2013; 4 (2):61-65.

DOI: 10.5005/jp-journals-10001-1141

Published Online: 01-12-2014

Copyright Statement:  Copyright © 2013; The Author(s).


Abstract

Introduction

Oral squamous cell carcinoma, the fifth most common cancer worldwide, is a major cause of morbidity and mortality in India. It most commonly occurs in middle-aged and older individuals. Typically, they tend to be preceded by a premalignant state for a long time. The present study evaluates the clinicopathological profile of patients with oral lesions and the role of malpractices that promote carcinogenesis in the oral mucosa and the use of Ki-67 as an important predictor of the same.

Materials and methods

The expression of Ki-67 was studied in paraffin-embedded tissue sections of oral lesions of all the cases after taking a detailed history and examination.

Results

The study was conducted on 65 patients with 25 dysplastic and 40 malignant lesions. Males were affected more frequently than females. The most common age group affected was 31 to 60 years with mean age of 45.4 years. Anterior twothird of tongue (41%) was the most commonly affected site. 95% of the patients had a history of addiction in form of smoking, tobacco chewing and betel nut. Out of 25 cases of dysplasia, 11 showed low expression while out of 40 cases of squamous cell carcinoma only three showed low and 29 showed high expression of Ki-67.

Conclusion

The expression of Ki-67 correlates well with the disease progression from dysplasia to carcinoma of the oral cavity. It is therefore a marker of malignant transformation and carcinogenesis in oral premalignant lesions and in future it may serve as a prognostic tool in the early detection of malignancy.

How to cite this article

Maheshwari V, Sharma SC, Narula V, Verma S, Jain A, Alam K. Prognostic and Predictive Impact of Ki-67 in Premalignant and Malignant Squamous Cell Lesions of Oral Cavity. Int J Head Neck Surg 2013;4(2):61-65.


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  1. Demographics and occurrence of oral and pharyngeal cancers. The outcomes, the trends, the challenge. J Am Dent Assoc 2001;132(Suppl):7S-11S.
  2. Risk factors for squamous cell carcinoma of the oral cavity in young people: A comprehensive literature review. Oral Oncology 2001 Jul;37(5):401-18.
  3. Prognostic significance of EGFR and Her-2 in oral cavity cancer in betel quid prevalent area cancer prognosis. Br J Cancer 2003 Aug 18;89(4):681-86.
  4. Understanding carcinogenesis for fighting oral cancer. J Oncol 2011, Article ID 603740, 10 pages.
  5. Oral cancer prevention and control: The approach of the World Health Organization. Oral Oncol 2009;45(4-5):454-60.
  6. Assessment of risk factors for oral squamous cell carcinoma in Chidambaram, Southern India: A case-control study. Europ J Can Prev 2007 June;16(3):251-56
  7. Tabacco, oral cancer and treatment of dependence. Oral Oncol 2005;41:244-60.
  8. Relationship between dental factors and risk of upper aerodigestive tract cancer. Oral Oncol 1998;34(4):284-91.
  9. Prognosis of oral premalignant lesions: Significance of clinical, histopathological and molecular biological characteristics. Crit Rev Oral Biol Med 2003;14:47.
  10. Predicting cancer development in oral leukoplakia: Ten years of translational research. Clin Can Res 2000;6:1702-10.
  11. Interventions for treating oral leukoplakia (Review). Cochrane Database Syst Rev 2006 Oct 18;4:CD001829.
  12. Marker of cell proliferation in normal epithelia and dysplastic leukoplakias of the oral cavity. Cancer Epidemiol Biomarkers Prev 1998;7:597-603.
  13. The Ki-67 protein from the known and the unknown. J Cell Physiol 2000;182:311-22.
  14. Is the Ki-67 labelling index ready for clinical use? Annals Oncol 2011;22:500-02.
  15. The cell proliferation-associated antigen of antibody Ki-67: A very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol 1993;123(3):513-22.
  16. Expression of Ki67 antigen and proliferative cell nuclear antigen in benign and malignant epithelial lesions of the larynx. J laryngol Otol 1996;110:440-45.
  17. The association between epithelial proliferation and disease progression in the oral mucosa. Oral Oncol 1999;35:409-14.
  18. The presence of p53 in relation to Ki67 as a cellular proliferation marker in head and neck squamous cell carcinoma and adjacent dysplastic mucosa. Oral Oncol Europ J Can 1994;30(B);138-414.
  19. Cell cycle dysregulation in oral cancer. Crit Rev Oral Biol Med 2002;13:151-61.
  20. A study of Ki-67, c-erbB2 and cyclin D-1 expression in CIN-I, CIN-III and squamous cell carcinoma of the cervix. Histol Histopathol 2007;22:587-92.
  21. Analysis of Ki-67 antigen expression, DNA proliferative fraction, and survival in resected cancer of the pancreas. Am J Surg 2003;186(5):486-92.
  22. Prognostic impact of immunohistochemical expression of Ki-67 in patients with advanced gastric cancer who underwent curative resection. J Clin Oncol 2011; (Supl 4):29.
  23. Ki-67 is an independent predictor of bladder cancer outcome in patients treated with radical cystectomy for organ-confined disease. Clin Can Res 2006 Dec 15;12(24):7369-73.
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