International Journal of Head and Neck Surgery

Register      Login

VOLUME 8 , ISSUE 2 ( April-June, 2017 ) > List of Articles

REVIEW ARTICLE

Role of Extracapsular Nodal Spread and Surgical Margin Status in defining High-risk Head and Neck Squamous Cell Carcinoma and its Treatment Intensity

Volkert B Wreesmann

Citation Information : Wreesmann VB. Role of Extracapsular Nodal Spread and Surgical Margin Status in defining High-risk Head and Neck Squamous Cell Carcinoma and its Treatment Intensity. Int J Head Neck Surg 2017; 8 (2):76-83.

DOI: 10.5005/jp-journals-10001-1310

License: CC BY 3.0

Published Online: 01-04-2013

Copyright Statement:  Copyright © 2017; The Author(s).


Abstract

How to cite this article

Wreesmann VB. Role of Extracapsular Nodal Spread and Surgical Margin Status in defining High-risk Head and Neck Squamous Cell Carcinoma and its Treatment Intensity. Int J Head Neck Surg 2017;8(2):76-83.


HTML PDF Share
  1. Molecular biology and immunology of head and neck cancer. Surg Oncol Clin N Am 2015 Jul;24(3):397-407.
  2. Clinical staging of cancer of the head and neck: a new “new” system. Am J Surg 1976 Oct;132(4):525-528.
  3. Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin 2017 Mar;67(2):122-137.
  4. Evaluation of the dose for postoperative radiation therapy of head and neck cancer: first report of a prospective randomized trial. Int J Radiat Oncol Biol Phys 1993 Apr 30;26(1):3-11.
  5. Epidermoid carcinoma of the head and neck, with special reference to metastasis. J Pathol Bacteriol 1930;33:501-526.
  6. Prognostic significance of histologic host response in cancer of the larynx or hypopharynx. Cancer 1971;28:1255-1265.
  7. Observer variation in the histopathologic assessment of extranodal tumor spread in lymph node metastases in the neck. Head Neck 2012 Jun;34(6):840-845.
  8. Influence of extracapsular nodal spread extent on prognosis of oral squamous cell carcinoma. Head Neck 2016 Apr;38 (Suppl 1):E1192-E1199.
  9. Prognostic significance of microscopic and macroscopic extracapsular spread from metastatic tumor in the cervical lymph nodes. Oral Oncol 2002 Dec;38(8):747-751.
  10. Extracapsular spread in head and neck squamous cell carcinoma: a systematic review and meta-analysis. Oral Oncol 2016 Nov;62:60-71.
  11. Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread. Oral Oncol 2003 Feb;39(2):130-137.
  12. Lymph node prognostic factors in head and neck squamous cell carcinomas. Am J Surg 1994 Nov;168(5):494-498.
  13. Extracapsular spread in the clinically negative neck (N0): implications and outcome. Otolaryngol Head Neck Surg 1996 Jan;114(1):65-70.
  14. The effect of occult nodal metastases on survival and regional control in patients with head and neck squamous cell carcinoma. Laryngoscope 2008 Jul;118(7):1191-1194.
  15. Efficacy of selective lymph node dissection in clinically negative neck. Otolaryngol Head Neck Surg 2002 Oct;127(4):279-283.
  16. Management of the N0 neck in moderately advanced squamous carcinoma of the larynx. Otolaryngol Head Neck Surg 2009 Jul;141(1):59-65.
  17. Quantitative analysis of the extent of extracapsular invasion and its prognostic significance: a prospective study of 170 cases of carcinoma of the larynx and hypopharynx. Head Neck 1998 Jan;20(1):16-21.
  18. The importance of margins in head and neck cancer. J Surg Oncol 2016 Mar;113(3):248-255.
  19. Surgical margins in head and neck cancer: a contemporary review. Head Neck 2013 Sep;35(9):1362-1370.
  20. Determining adequate margins in head and neck cancers: practice and continued challenges. Curr Oncol Rep 2016 Sep;18(9):54.
  21. Surgical margins in head and neck squamous cell carcinoma: what is ‘close'? Eur Arch Otorhinolaryngol 2013 Sep;270(10):2603-2609.
  22. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 2001 Nov 1;51(3):571-578.
  23. Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: report on Intergroup Study 0034. Int J Radiat Oncol Biol Phys 1992;23(4):705-713.
  24. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 2004 May 6;350(19):1937-1944.
  25. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 2004 May 6;350(19):1945-1952.
  26. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck 2005 Oct;27(10):843-850.
  27. Long-term follow-up of the RTOG 9501/intergroup phase III trial: postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 2012 Dec 1;84(5):1198-1205.
  28. Beyond positive margins and extracapsular extension: evaluating the utilization and clinical impact of postoperative chemoradiotherapy in resected locally advanced head and neck cancer. J Clin Oncol 2017 May 10;35(14):1550-1560.
  29. A proposal to redefine close surgical margins in squamous cell carcinoma of the oral tongue. JAMA Otolaryngol Head Neck Surg 2017 Mar 9.
  30. Extent of extracapsular spread: a critical prognosticator in oral tongue cancer. Cancer 2003 Mar 15;97(6):1464-1470.
  31. Influence of close resection margins on local recurrence and disease-specific survival in oral and oropharyngeal carcinoma. Br J Oral Maxillofac Surg 2012 Mar;50(2):102-108.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.