International Journal of Head and Neck Surgery

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VOLUME 12 , ISSUE 2 ( April-June, 2021 ) > List of Articles

REVIEW ARTICLE

Lhermitte–Duclos Disease: Case Report and Literature Review

Brajesh Kumar, Samrendra Kumar Singh, Om Prakash Gupta, KM Jha

Keywords : Dysplastic gangliocytoma, Headache, Lhermitte–Duclos disease

Citation Information : Kumar B, Singh SK, Gupta OP, Jha K. Lhermitte–Duclos Disease: Case Report and Literature Review. Int J Head Neck Surg 2021; 12 (2):65-70.

DOI: 10.5005/jp-journals-10001-1424

License: CC BY-NC 4.0

Published Online: 01-06-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Lhermitte–Duclos disease (LDD) is a neurological disorder caused by a hamartomatous lesion within the cerebellum. Clinically, LDD is often associated with symptoms of the space-occupying lesion due to increased intracranial pressure, hydrocephalus, and focal neurological deficit. This was a case of a 36-year-old woman who presented with progressive headache and difficulty in swallowing liquids. Magnetic resonance imaging demonstrated a right cerebellar mass lesion with the characteristic “tiger-striped appearance”. There was an inferior displacement of the right cerebellar tonsil. She underwent ventriculoperitoneal (VP) shunt and followed by partial resection of the tumor to decrease the mass effect. Her headache gradually improved and she was able to swallow liquids by the time of discharge.


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  1. Nowak DA, Trost HA. Lhermitte-Duclos disease (dysplasticcerebellar gangliocytoma): a malformation, hamartoma or neoplasm? Acta Neurol Scand 2002;105(3):137–145. DOI: 10.1034/j.1600-0404.2002.1r127.x.
  2. Andres RH, Guzman R, Weis J, et al. Lhermitte-Duclos disease with atypical vascularization - case report and review of the literature. Clin Neuropathol 2009;28(03):83–90. DOI: 10.5414/NPP28083.
  3. Ishizaki K, Daita G, Yonemasu Y, et al. Hypervascularity in Lhermitte-Duclos disease-case report. Neurol Med Chir (Tokyo) 1997;37(5):403–406. DOI: 10.2176/nmc.37.403.
  4. Moonis G, Ibrahim M, Melhem ER. Diffusion-weighted MRI in Lhermitte-Duclos disease: report of two cases. Neuroradiology 2004;46(5):351–354. DOI: 10.1007/s00234-004-1190-6.
  5. Afshar-Oromieh A, Linhart H, Podlesek D, et al. Postoperative cerebellar mutism in adult patients with Lhermitte-Duclos disease. Neurosurg Rev 2010;33(4):401–408. DOI: 10.1007/s10143-010- 0278-1.
  6. Goto Y, Hashimoto N, Okita Y, et al. A surgically treated case of Lhermitte-Duclos disease with a precise natural history and high uptake of FDG on PET. J Neurooncol 2010;97(3):445–450. DOI: 10.1007/s11060-009-0042-y.
  7. Zou YH, Cao YQ, Yue ZJ, et al. Unusual posterior fossa mass caused by Lhermitte-Duclos disease with no symptoms in adults. Br J Neurosurg 2011;26(1):99–101. DOI: 10.3109/02688697.2011.591851.
  8. Inoue T, Nishimura S, Hayashi N, et al. Ectopic recurrence of dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease): a case report. Brain Tumor Pathol 2007;24(1):25–29. DOI: 10.1007/s10014-006-0211-z.
  9. Takei H, Dauser R, Su J, et al. Anaplastic ganglioglioma arising from a Lhermitte-Duclos-like lesion. Case report. J Neurosurg 2007;107:137–142.
  10. Nakagawa T, Maeda M, Kato M, et al. A case of Lhermitte-Duclos disease presenting high FDG uptake on FDG-PET/CT. J Neurooncol 2007;84(2):185–188. DOI: 10.1007/s11060-007-9355-x.
  11. Yang MS, Kim CH, Cheong JH, et al. Lhermitte-Duclos disease presenting with hydrocephalus. Acta Neurochir Suppl 2012;113: 161–165.
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